• Scientist III Process Development

    Job Location US-TN-Memphis
    Job ID
    Therapeutics Prod & Quality
  • Summary

    St. Jude Children’s Research Hospital was the first pediatric cancer research center in the U.S. to open its own on-site GMP facility, Children’s GMP, LLC. Now St. Jude, a federally-designated Hemophilia Treatment Center, is working to bring a new hemophilia gene therapy to patients in countries where access to treatment is low and the standard of care is poor. The process development team is working on a novel process to manufacture and purify this new AAV-based gene therapy so the GMP team can manufacture sufficient quantities to meet the clinical research needs in these countries. If successful, this project has the potential to bring a cure to hemophilia B patients in these populations.


    Under daily supervision, the Scientist III will support upstream and downstream process development experiments as needed. This includes cell culture in shake flasks and bioreactors, bioreactor setup and maintenance, virus purification using AKTA chromatography systems, filtration, and related activities. The ideal candidate will have experience in at least one of these areas, as well as with basic molecular biology techniques.


    Other essential duties include recording experimental details via electronic notebook; assistance in drafting production batch records in close collaboration with the Quality Assurance Department of Children’s GMP, LLC; and lending support in cGMP manufacturing.


    Applicants should enjoy working on a team, be quick to learn new skills, display attention to detail, and show commitment to the mission of St. Jude.

    Minimum Education

    Bachelor's degree in Biological Sciences, Chemical Engineering or Bioprocessing or related field required

    Minimum Experience

    Two (2) years of related experience with BS. No experience required with an appropriate MS or Ph.D. Experience in a cGMP environment is preferred but not required.


    St. Jude is an Equal Opportunity Employer


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